0{{current_slide_index}} 0{{total_slide_count}} Hydroxyurea 1998 Is the first drug approved to treat sickle cell disease in adults. Find a Clinical Trial 2024 20+ 0{{current_slide_index}} 0{{total_slide_count}} no fda approval in 20+ years Hydroxyurea is the only approved medication with proven benefits for the treatment of SCA for 20+ years. Find a Clinical Trial 20+ 2017 0{{current_slide_index}} 0{{total_slide_count}} L-glutamine & Hydroxyurea 2017 L-glutamine (Endari): Approved to treat sickle cell disease in adults and children. Hydroxyurea (Siklos): Approved to treat sickle cell disease in children. Find a Clinical Trial 20+ 2019 0{{current_slide_index}} 0{{total_slide_count}} Crizanlizumab & Voxelotor 2019 Crizanlizumab (Adakveo): Approved to treat pain crises in adults and pediatric patients 16 years and older. Voxelotor (Oxbryta): Approved to help prevent sickling in patients 12 years and older. Find a Clinical Trial 2017 2023 0{{current_slide_index}} 0{{total_slide_count}} Casgevy & Lyfgenia 2023 Casgevy: Approved for the treatment of sickle cell disease in patients 12 years of age and older with recurrent vaso-occlusive crises. Casgevy is the first FDA-approved therapy utilizing the CRISPR genome editing technology.

Lyfgenia: Approved for the treatment of patients 12 years of age and older with sickle cell disease and a history of vaso-occlusive events.
Find a Clinical Trial
2019 2024
0{{current_slide_index}} 0{{total_slide_count}} Voxelotor (Oxbryta) 2024 Voluntarily withdrawn from the market worldwide Find a Clinical Trial 2023 1998

We need new treatments for sickle cell.

There’s more Hope on the Horizon!

Clinical studies are looking for participants so that they can conduct the research necessary to improve understanding about potential treatments.

More Hope on the Horizon

Clinical studies happen in phases, as researchers learn more about the safety and effectiveness of the new drug for humans. Watch to learn about the three main phases of clinical trials. Clinical trials are research studies that involve people. Understanding what they are can help you decide if a clinical trial might be an option for you or a loved one

Clinical Trial Finder

Sickle Cell Disease Association of America’s Clinical Trial Finder was created in partnership with Forma Therapeutics. Our Clinical Trial Finder is a centralized, simple-to-navigate resource that helps people with sickle cell disease, their families and caregivers find clinical trials. Clinical trials help pharmaceutical companies and researchers develop new sickle cell treatments.

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Take our “Ask Your Doctor” sheet to your physician to start a conversation about clinical studies. There are 5 questions that will help you learn more about studies in your area.

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ClinicalTrials.gov is a database of privately and publicly funded clinical studies conducted around the world. Explore 259,383 research studies in all 50 states and in 201 countries.

ClinicalTrials.gov is a resource provided by the U.S. National Library of Medicine.

The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the nation’s medical research agency — making important discoveries that improve health and save lives.

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The FDA's organization consists of the Office of the Commissioner and four directorates overseeing the core functions of the agency: Medical Products and Tobacco, Foods, Global Regulatory Operations and Policy, and Operations.

CDC laboratories routinely work with some of the most deadly germs in the world – identifying health threats and conducting vital public health research. CDC constantly develops and reviews extensive laboratory guidelines and procedures to protect both the public and laboratory workers.

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Our vision is a world without sickle cell disease

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